Endocrine Abstracts

Background: Obesity is associated with increased atherogenesis through alterations in lipids, among other potential factors. Some of those abnormalities might be mediated by insulin resistance (IR).Aims: To compare lipid and apolipoprotein profile between lean and obese women; to evaluate the influence of IR on lipid and apolipoprotein profile, in obese women.Methods: We studied 112 obese and 100 normal-weight premenopausal women w...

Background and Aim: Unacylated ghrelin (UAG) is the major form of circulating ghrelin. Initially considered as a non-functional peptide, soon after UAG has been associated to a negative action on energy balance, suppression of hepatic glucose production and decrease in circulating levels of insulin. The aim of this study was to analyze the association between the serum levels of UAG and glucose metabolism parameters in obese women, independently from the eventual interference ...

Background: Obesity represents a cardiovascular risk factor. Monocyte chemoattractant protein-1 (MCP-1) is a known regulator of monocyte recruitment to sites of inflammation, and participates at the early phases of atherogenesis. Apolipoproteins, as part of the lipoprotein particles, are classically coupled with cardiovascular risk distinction.Aims: To assess the association of anthropometric parameters, insulin resistance and MCP-1 levels with classic l...

Background: Although acyl–ghrelin has been considered essential for ghrelin’s GH-releasing activity, several recent in vitro studies have shown that desacyl–ghrelin exhibits biological activities on metabolism and proliferation of adipocytes, myocytes, cardiomyocytes, and myelocytes. The full desacyl–ghrelin biological activity still remains a matter of debate.Aims: To assess desacyl–ghrelin circulating levels and its R51Q...

Background: Adiponectin is an adipokine with anti-diabetic properties. Recently, retinol binding protein-4 (RBP4) was identified as an adipokine associated with insulin resistance (IR) and a potential marker for type 2 diabetes (T2D) development.Aims: To compare adiponectin and RBP4 circulating levels according to presence/absence of diabetes/prediabetes, in obese women. To study the degree of association of those adipokines with indexes of IR and insuli...

Background: Adiponectin is an important adipokine to which have been attributed anti-diabetic and anti-atherogenic properties. Excess of abdominal fat deposition is undoubtedly assumed as a cardiometabolic risk factor. It has been hypothesized that peripheral deposition of fat could exert a protective effect in cardiometabolic profile.Aims: To evaluate the influence of anthropometric parameters on adiponectin levels in both obese and normal-weight premen...